SPRING 2004 SEMINAR SERIES

Abstract: Applications of DNA Microarrays to Biomedical Research and Molecular Diagnostics

Steve Laderman, Ph.D.
R & D Dept. Manager, Molecular Diagnostics, Agilent Labs

Applications of modern, high-throughput, highly multiplexed bio-molecular measurement systems to the analysis of complex diseases are leading to the discovery of characteristic molecular phenotypes and associated genotypes that correlate to disease pre-disposition, clinical symptoms, and responses to therapy. Such discoveries both accelerate the invention and development of new therapies and reveal potential strategies for increasing the precision and timeliness of diagnostic methods. To create and optimize diagnostic methods that emerge from such studies, it is essential to establish the precise information content required. The search for such parameters in this rapidly evolving field at the interface of biology, chemistry, physics, mathematics, computer science, and engineering is greatly aided by high quality, robust, and flexible measurement systems along with computation tools that emphasize transparent and efficient algorithms. Insights obtained in this way directly contribute to extension and refinement of the methods themselves, creating additional needs and opportunities for advances.

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